Main
Albert Henry
I am a research fellow at University College London (UCL), UK. Previously, I did a PhD on Cardiovascular Genetics at UCL sponsored by the British Heart Foundation Cardiovascular Biomedicine 4-year PhD studentship. Prior to my PhD, I trained and practiced as a clinician (general practice) in Indonesia, and I had an MSc degree in Health and Biomedical Data Science from UCL. In my research, I am working at the intersection of data science, human genetics, and drug target validation within the field of cardiovascular diseases. My research interest is integrating computational methods, statistics, and data visualization to elucidate causal biology and to identify therapeutic targets for complex cardiovascular diseases using large-scale genetic and deep phenotype data.
Education
PhD, Cardiovascular Genetics
Institute of Cardiovascular Science
University College London, UK
2023 - 2018
- Thesis: Understanding heart failure using human genetics
MSc, Data Science for Research in Health and Biomedicine
Institute of Health Informatics
University College London, UK
2017 - 2016
- Dissertation: A Mendelian randomization study investigating the causal association between sleep duration and cognitive functions
- Graduated with distincition
- Listed in Faculty Dean’s List of Top Performing Students
MD
Diponegoro University
Semarang, Indonesia
2014 - 2007
- Graduated cum laude
Professional Experience
Research fellow
Institute of Health Informatics
University College London, UK
current - 2022
- Built a high-throughput computational pipeline and led the analysis for drug target validation using large-scale genomics and proteomics data
Visiting scientist
Broad Institute of MIT and Harvard
Cambridge, MA, USA
2022 - 2022
- Visiting scientist at the Broad Institute Precision Cardiology Laboratory
- Research project: Functional profiling of genomic loci for heart failure with singe-nuclei RNA sequencing
Research assistant
Institute of Health Informatics
University College London, UK
2018
- Performed statistical analysis, data visualisation, and prepared manuscript for genome-wide association study meta-analysis of heart failure
Laboratory intern
Center for Biomedical Research
Semarang, Indonesia
2016
- Performed DNA extraction and cytogenetic analysis
General practitioner
Puskesmas (public health centre) Ambarawa
Ambarawa, Indonesia
2015
- Carried out GP services and health promotion programmes
Emergency room doctor
RSUD (district hospital) Ambarawa
Ambarawa, Indonesia
2014
- Carried out emergency clinical services
Visiting medical student
Radboud University
Nijmegen, The Netherlands
2013
- Studied Neglected Tropical Disease and International Public Health
Teaching Experience
Advanced Statistical Analysis & Advance Statistics in Records Research
Institute of Health Informatics
University College London, UK
current - 2020
- Developed teaching materials and lectured in risk prediction & Messy Data Challenge
- Online slides: https://ihi-risk-teaching.netlify.app/
Computational Genetics in Healthcare
Institute of Health Informatics
University College London, UK
2022 - 2021
- Developed practical materials and served as teaching assistants.
- Topics include Mendelian randomization, GWAS, Polygenic Risk Score, Rare-variant association analysis, and GWAS meta-analysis
Computational Methods in Biodiversity Research
Department of Genetics, Evolution and Environment
University College London, UK
2022 - 2021
- Served as teaching assistants in introduction to data science and statistics with R
Introduction to data visualisation with R
Code Club
University College London, UK
2020
- Developed materials and delivered an online workshop to visualize Covid-19 case rate with R and ggplot2
- Material: https://github.com/IHI-Code-Club/data-viz
Training & Certifications
Computational Systems Biology for Complex Human Disease
Wellcome Genome Campus Advanced Courses
Cambridge, UK
2021
NVIDIA-DIRAC AI Bootcamp
University College London
University College London, UK
2019
Data Visualisation for Biology
European Bioinformatics Institute (EMBL-EBI)
Cambridge, UK
2019
Statistical Analysis of Genetic Association Studies
University of Liverpool
Liverpool, UK
2018
Exploring Human Genetic Variation
European Bioinformatics Institute (EMBL-EBI)
Cambridge, UK
2018
Understanding the genetic architecture of complex traitst through SNP-based heritability analysis
University College London
University College London, UK
2018
Genetic Association Studies and Mendelian Randomization
University College London
University College London, UK
2017
Talks
Genetic analysis in 1.9 million individuals reveals new insights into genetic variation underlying heart failure susceptibility
European Society of Human Genetics Conference
N/A
2023
- Presented in oral session
Estimating the causal associations between plasma protetins and heart failure using Mendelian randomization
Workshop: Accelerating Precision Medicine with data science
Örsundsbro, Sweden
2020
- Invited and sponsored by Olink Proetomics
Large-scale genome-wide association study of heart failure identifies novel susceptibility loci and provides a platform for drug target validation
EMBL Conference: Target Validation Using Genomics and Informatics
Heidelberg, Germany
2019
- Presented in poster session
Sleep duration and cognition: Application of linear and non-linear Mendelian randomization in UK Biobank
South England Genetic Epidemiology Group (SEGEG) meeting
Oxford, UK
2019
Other activities
UCL Code Clubs
N/A
University College London, UK
current - 2019
- Co-lead of UCL Code Clubs, a volunteer-led group based at UCL aiming to introduce and encourage good coding practice and reproducibility in computational research
The IHI Code Club Hackathon 2020+1
Institute of Health Informatics
University College London, UK
2021
- Co-organise the IHI Code Club Hackathon 2020+1, a 3-day virtual collaborative public hackathon event to solve real-world issues in health data science
Grants & Awards
American Society of Human Genetics Annual Meeting 2023
N/A
Washington D.C., USA
2023
- ASHG Trainee Research Excellence Award Winner (predoctoral category)
Indonesian Society of Human Genetics Annual Meeting 2023
N/A
Makassar, Indonesia
2023
- Best oral presentation
UCL Access and Widening Participation Bespoke Project Awards
N/A
University College London, UK
2022
- £3000 funding for ‘One Data Science’ project: introducing data science and statistics to A-level students across the UK
UCL eResearch Community-Based Initiatives 2021
N/A
University College London, UK
2021
- £500 funding for UCL Code Clubs
UCL eResearch Community-Based Initiatives 2020
N/A
University College London, UK
2020
- £500 funding for UCL Code Clubs
UCL Researcher-led Initiatives 2020
N/A
University College London, UK
2020
- £1000 funding for IHI Code Club Hackathon
London Genetics Network inaugural meeting 2020
N/A
London, UK
2020
- Best poster
- Poster title: Mendelian randomization analysis of circulating protein levels for therapeutic target prioritization in heart failure
Alzheimer’s Indonesia conference 2017
N/A
Jakarta, Indonesia
2017
- Best poster
- Poster title: How sleep genes affect cognition – a Mendelian randomization study in UK Biobank
Selected Publications
Large-scale genome-wide association study of dilated cardiomyopathy in over one million participants identifies genes, pathways, and cellular communications contributing to pathology
Manuscript in review
N/A
2023
- Sean Zheng, Albert Henry (joint first author), …
Genetic analysis in 1.9 million individuals provides insights into the causal aetiology underlying heart failure subtypes
Manuscript in review
N/A
2023
- Albert Henry, …
Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity
Science Advances
N/A
2023
- Amand F Schmidt, …, Albert Henry, …, Jessica van Setten, Chris Finan
The relationship between adiposity and cognitive function: a bidirectional Mendelian randomization study in UK Biobank
International Journal of Epidemiology
N/A
2023
- Tom Norris, Antoine Salzmann, Albert Henry, Victoria Garfield, Snehal M Pinto Pereira
Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study
The Lancet Digital Health
N/A
2023
- Valerie Kuan, …, Albert Henry, …, Harry Hemingway, Aroon D Hingorani
Coupled myovascular expansion directs cardiac growth and regeneration
Development
N/A
2022
- Paige DeBenedittis, Anish Karpurapu, Albert Henry, …, R Thomas Lumbers, Ravi Karra
Therapeutic targets for heart failure identified using proteomics and Mendelian randomization
Circulation
N/A
2022
- Albert Henry, María Gordillo-Marañón, Chris Finan, Amand F Schmidt, …, R Thomas Lumbers
The genomics of heart failure: design and rationale of the HERMES consortium
ESC Heart Failure
N/A
2021
- R Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I Swerdlow, …
Estimating the effect of reduced attendance at emergency departments for suspected cardiac conditions on cardiac mortality during the COVID-19 pandemic
Circulation: Cardiovascular Quality and Outcomes
N/A
2021
- Michail Katsoulis, Manuel Gomes, Alvina G Lai, Albert Henry, Spiros Denaxas, Pagona Lagiou, Vahe Nafilyan, Ben Humberstone, Amitava Banerjee, Harry Hemingway, R Thomas Lumbers
Life-Time Covariation of Major Cardiovascular Diseases: A 40-Year Longitudinal Study and Genetic Studies
Circulation: Genomic and Precision Medicine
N/A
2021
- Lars Lind, Johan Sundström, Johan Ärnlöv, Martin Ingelsson, Albert Henry, R Thomas Lumbers, Erik Lampa
Genetic and functional insights into the fractal structure of the heart
Nature
N/A
2020
- Hannah V Meyer, … Albert Henry …, Ewan Birney, Declan P O’Regan
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Nature Communications
N/A
2020
- Sonia Shah, Albert Henry (joint first authors), …, R. Thomas Lumbers
The relationship between sleep duration, cognition and dementia: a Mendelian randomization study
International Journal of Epidemiology
N/A
2019
- Albert Henry, Michail Katsoulis, Stefano Masi, Ghazaleh Fatemifar, Spiros Denaxas, Dionisio Acosta, Victoria Garfield, Caroline E Dale